Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection.

Elevated Numbers of Fc RIIIA (CD16 ) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Innate and Adaptive Cellular Immunity in Chronic HCV and HIV-1 Infection

Viral infections are initially countered by an innate immune response as a first line of defence followed by an adaptive immune response. However, certain viruses successfully evade cellular immune responses and establish chronic infection. Hepatitis C virus (HCV) and Human Immunodeficiency Virus 1 (HIV-1) are chronic viral infections on the rise globally. HCV/HIV-1 co-infection presents a form...

Physical and functional association of p56lck with Fc gamma RIIIA (CD16) in natural killer cells

The transmembrane receptor for immunoglobulin G immune complexes on natural killer (NK) cells and macrophages, Fc gamma RIIIA (CD16), mediates cellular activation through a tyrosine kinase-dependent pathway. We show that Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells and demonstrate a physical association of p56lck with Fc gamma RIIIA in immunoprec...

بررسی فتوتیپ‌های سلولیNatural killer (NK) و سلول‌های شبه Natural killer T(NKT) در بیماران مبتلا به زخم پپتیک و سرطان معده‌ی ناشی از عفونت هلیکوباکتر پیلوری

Background and purpose: The aim of this study was to compare the proportion of natural killer (NK) and natural killer T (NKT)-like cells in dyspeptic disorders caused by Helicobacter pylori (H. pylori). Materials and methods: In a case-control study, 27 patients with gastric cancer (GC), 25 patients with peptic ulcer (PUD), and 22 patients with non-ulcer dyspepsia (NUD) were enrolled. After en...

Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections.

We found an unusual fc gamma receptor IIIa (CD16) phenotype on the natural killer (NK) cells of a 3-year-old boy, who suffered from recurrent viral respiratory tract infections since birth. He also had severe clinical problems after Bacille Calmette-Geérin (BCG) vaccination and following Epstein-Barr virus and Varicella Zoster virus infections. His peripheral blood lymphocytes contained a norma...